Introduction
1. The Human Microbiome
2. Microbial Pathogens Drive Certain Cancers
3. Metagenomic Sequencing Studies Reveal Associations between Commensal Bacteria and Cancer Incidence
4. Gnotobiotic Mouse Models Demonstrate. Causality and Provide Mechanistic Insights
5. Microbial Mechanisms of Oncogenesis and Tumor Suppression
5.1. Immune System and Inflammation
5.2. Diet and Microbial Metabolites
5.3. Cell Signaling Pathways
5.4. DNA Damage
5.5. Distant Sites
6. Cancer Treatment
6.1. Immunotherapy
6.2. Chemotherapy
6.3. Microbial Drug Targets in Oncology
6.4. Future Directions
References
1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016; 66: 7-30.
2. Mariotto AB, Yabroff KR, Shao Y, Feuer EJ, Brown ML. Projections of the cost of cancer care in the United States: 2010- 2020. J Natl Cancer Inst. 2011; 103: 117- 128.
3. Tomasetti C, Vogelstein B. Cancer etiology. The number of stem cell divisions can explain variation in cancer risk among tissues. Science. 2015; 347: 78-81.
4. Ashford NA, Bauman P, Brown HS, et al. Cancer risk: role of environment [serial online]. Science. 2015; 347: 727.
5. Harris CC. Editorial. Carcinogenesis. 2016; 37:1.
6. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Biological agents. Volume 100 B. A review of human carcinogens. IARC Monogr Eval Carcinog Risks Hum. 2012; 100(pt B): 1-441.
7. Anand P, Kunnumakkara AB, Sundaram C, et al. Cancer is a preventable disease that requires major lifestyle changes. Pharm Res. 2008; 25:2097-2116.
8. Willett WC. Diet and cancer. Oncologist. 2000; 5:393-404.
9. Goodrich JK, Di Rienzi SC, Poole AC, et al. Conducting a microbiome study. Cell. 2014; 158:250-262.
10. Weinstock GM. Genomic approaches to studying the human microbiota. Nature. 2012; 489:250-256.
11. Morgan XC, Huttenhower C. Chapter 12: human microbiome analysis [serial online]. PLoS Comput Biol. 2012; 8: e1002808.
12. Arumugam M, Raes J, Pelletier E, et al. Enterotypes of the human gut microbiome. Nature. 2011; 473:174-180.
13. Sender R, Fuchs S, Milo R. Are we really vastly outnumbered? Revisiting the ratio of bacterial to host cells in humans. Cell. 2016;164:337-340.
14. Savage DC. Microbial ecology of the gastrointestinal tract. Annu Rev Microbiol. 1977; 31:107-133.
15. Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011; 140:1713-1719.
16. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota [serial online]. PLoS Biol. 2007; 5:e177.
17. Dominguez-Bello MG, Costello EK, Contreras M, et al. Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010; 107:11971-11975.
18. Claesson MJ, Cusack S, O’Sullivan O, et al. Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proc Natl Acad Sci U S A. 2011; 108(suppl 1):4586-4591.
19. Biagi E, Nylund L, Candela M, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010; 5: e10667.
20. Goodrich JK, Waters JL, Poole AC, et al. Human genetics shape the gut microbiome. Cell. 2014; 159:789-799.
21. Benson AK. The gut microbiome-an emerging complex trait. Nat Genet. 2016; 48:1301-1302.
22. Wang J, Thingholm LB, Skieceviciene J, et al. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat Genet. 2016; 48:1396- 1406.
23. Bonder MJ, Kurilshikov A, Tigchelaar EF, et al. The effect of host genetics on the gut microbiome. Nat Genet. 2016;48:1407- 1412.
24. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014; 505:559-563.
25. Xu Z, Knight R. Dietary effects on human gut microbiome diversity. Br J Nutr. 2015; 113(suppl):S1-S5.
26. Sonnenburg ED, Smits SA, Tikhonov M, Higginbottom SK, Wingreen NS, Sonnenburg JL. Diet-induced extinctions in the gut microbiota compound over generations. Nature. 2016; 529:212-215.
27. David LA, Materna AC, Friedman J, et al. Host lifestyle affects human microbiota on daily timescales [serial online]. Genome Biol. 2014; 15:R89.