Перечень использованных сокращений
Введение
1. Обзор литературы
Профессиональные факторы риска возникновения рака
1. 1. Факторы риска канцерогенеза.
1.2. Взаимосвязь между условиями профессиональной деятельности и риском возникновения рака.
2. Материалы и методы
2.1 Объект исследования.
2.2 Материалы и оборудование
2.3 Этапы проведенного исследования.
2.4 Статистическая обработка данных.
3. Результаты и их обсуждение
3.1 Процентное распределение онкологических заболеваний среди отобранных пациентов.
3.2 Процентное распределение онкологических заболеваний в пределах одного вида профессиональной деятельности.
3.3 Статистическое подтверждение зависимости между возникновением злокачественного новообразования и видом профессиональной сферы деятельности
Заключение
Список использованных источников
1. A critical review of the relationship between occupational exposure to diesel emissions and lung cancer risk / M. Möhner [et al.] // Critical Reviews in Toxicology/ - 2017. – Vol. 32. . P. 1-41.27
2. A review of human carcinogens—Part D: radiation / C.P. Shah [et al.] // Chemical Agents and Related Occupations. – 2009. – Vol. 10. – P. 751-752.9
3. Adenomas - Genetic factors in colorectal cancer prevention / K. Witold [et al.] // Rep Pract Oncol Radiother. – 2018. – Vol. 23, № 2. – P. 75-83.34
4. Aetiology of cancer in Asia / S. Park [et al.] // Asian Pacific J Cancer Prev. – 2008. – Vol. 9. – P. 371-380. 12
5. Bauer, A. Hautkrebs als berufserkrankung / A. Bauer // Leitthema. – 2016. – Vol. x. – P. 1-7.24
6. Behavioural interventions to promote workers’ use of respiratory protective equipment / B. Y. Luong Thanh [et al.] // Cochrane Database of Systematic Reviews. – 2016. – Vol. 12. – P. 1-74. 19
7. Boffetta, P. Human cancer from environmental pollutants: The epidemiological evidence / P. Boffetta // Mutation Research. – 2006. – Vol. 608. – P. 157–162. 15
8. Challenges and Opportunities for Occupational Epidemiologyin the Twenty-first Century / L.T. Stayner [et al.] // Curr Envir Health Rpt. – 2017. – Vol. x. – P. 1-6. 31
9. Clinicopathological significance of hypoxia-inducible factor-1 alpha (HIF-1a) expression in gastric cancer / Taro Isobe [et al.] // Int J Clin Oncol. – 2013. – Vol. 18. P. 293-304.36
10. Cobalt toxicity in humans. A review of the potentialsources and systemic health effects / L. Leyssens [et al.] // Toxicology. – 2017. – Vol. 17. – P. 1-56.26
11. Correlation of cervical cancer mortality with reproductive and dietary factors, and serum markers in China / Wan-De Guo [et al.] // International Journal of Epidemiology. – 1994. - Vol. 23, № 6. – P. 1127–1132. 14
12. Dermal exposure to toluene diisocyanate and respiratory cancer risk / L. Robyn [et al.] // Environment International. – 2017. – Vol. x. – P. 1-12.22
13. Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis / A. Kabir [et al.] // Iran J Public Health. – 2018. - Vol. 47, № 2. - P. 148-155. 25
14. Environmental and occupational causesof cancer: review of recent scientific literature / R. Clapp [et al.] // The Lowell Center for Sustainable Production. – 2005. – Vol. x. – P. 1-12. 18
15. Evaluation based on systematic review of epidemiological evidence among Japanese populations: tobacco smoking and total cancer risk / M. Inoue1 [et al.] // J ClinOncol. - 2005. – Vol. 35, № 7. – P. 404–411.13
16. Expression of survivin in gastric cancer and its relationship with tumor angiogenesis. / G.H. Lee [et al.] // Eur J GastroenterolHepatol. – 2006. – Vol. 18. – P. 957-963.5
17. Genetic Polymorphism of the Glutathione S-transferase Pi 1 (GSTP1) and Susceptibility to Cervical Cancer in Human Papilloma Virus Infected Northeastern Thai Women / S. Phuthong // Asian Pac J Cancer Prev. – 2018. – Vol. 19, № 2. – P. 381-385.33
18. HCCP (Harvard Center for Cancer Prevention). Human causes of cancer: Harvard School of Public Health, [www.hsph.harvard.edu/cancer/resources_materials/reports/index.htm] 1996.16
19. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor / Ishikawa F [et al.] // Nature. – 1989. – Vol. 38. – P. 557–562.37
20. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. / D. Lazăr [et al.] // Rom J MorpholEmbryol. – 2008. – Vol.49. – P. 371-379.4
21. Lifestyle-related factors and environmental agents causing cancer: An overview / P. Irigaraya [et al.] // Biomedicine & Pharmacotherapy . – 2007. – Vol. 61. – P. 640-658.1
22. Listing occupational carcinogens / J. Siemiatycki [et al.] // Environ Health Perspect. - 2004. Vol. 112. – P. 1447- 1459.17
23. Medical sciences topoisomerase levels determine chemotherapy response in vitro and in vivo / J.B. Darren [et al.] // ProcNatlAcad Sci. – 2008. – Vol.105. – P. 9053-9058.2
24. MicroRNA Processing Gene Methylation and Cancer Risk / B. T. .Joyce [et al.] // Cancer Epidemiol Biomarkers Prev. – 2018. – Vol. x. – P. 1-7. 35
25. Mohner, M. The impact of selection bias due to increasing responserates among population controls in occupational case-control studies / M. Mohner // Am J RespirCrit Care Med. – 2012. – Vol. 185. – P. 104–106.29
26. Multidisciplinary European Low Dose Initiative (MELODI): strategic research agenda for low dose radiation risk research / M. Kreuzer1 [et al.] // Radiation and Environmental Biophysics. – 2017. – Vol. x. – P. 1-11. 10
27. Noncoding RNAs Regulating p53 and c-Myc Signaling / Mei Y, Wu M // Adv Exp Med Biol. – 2016. – Vol. 927. – P. 337-365. 42
28. Occupational exposure to crystalline silica and gastric cancer: a systematic review and meta-analysis / W. Lee [et al.] // Occup Environ Med. – 2016. Vol. 73. P. 794–801. 20
29. Overview of occupational cancer inpainters in Korea / Jun-Pyo Myong [et al.] // Myonget al. Annals of Occupational and Environmental Medicine. – 2018. – Vol. 30. – P. 1-10.23
30. Oxidative damage infoundry workers occupationally co-exposed to PAHs and metals / Hung-Hsin Liu [et al.] // Int. J. Hyg. Environ. Health. – 2010. – Vol. 213. – P. 93–98.21
31. Phosphatase of regenerating liver-3 promotes migration and invasion by upregulating matrix metalloproteinases-7 in human colorectal cancer cells. / S.K. Lee [et al.] // Int J Cancer. – 2012. – Vol.131. – P. 190-203.6
32. Polymorphisms in the Thymidylate Synthase Gene and Risk of Colorectal Cancer / Chang-Ming Gao [et al.] // Asian Pacific Journal of Cancer Prevention. – 2012. – Vol. 13. – P. 4087-4091.7
33. Preston, J. R. International organizations, risk assessment and research–Why, what and how / R. J. Preston // Mutation Research. – 2017. – Vol. 17. – P. 1-5. 11
34. Prognostic value of expression of ERCC1, thymidylate synthase, and glutathione S-transferase P1 for 5-fluorouracil/oxaliplatin chemotherapy in advanced gastric cancer / H.C. Kwon [et al.] // Annals of Oncolog. – 2007. – Vol.18. – P. 504-509.3
35. Re: the hidden impact of a healthy-worker effect on the resultsof the Diesel Exhaust in Miners Study / D. T. Silverman [et al.] // Eur J Epidemiol. – 2016. – Vol. 31. – P. 805–806.30
36. RUNX3 and p53: How Two Tumor Suppressors Cooperate Against Oncogenic Ras? / J.W. Lee [et al.] // Adv Exp Med Biol. – 2017. – Vol. 962. – P. 321-332. 41
37. TGF-β1 genetic variants predict clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy / Li G [et al.] // Clin Cancer Res. – 2018. – Vol. 20. – P. 1-6.32
38. The Diesel Exhaust in Miners Study: a cohortmortality study with emphasis on lung cancer / M. D. Attfield [et al.] // J Natl Cancer Inst. – 2012. – Vol. 104. – P. 869–883.28
39. The network of epithelial–mesenchymal transition: potential new targets for tumor resistance / Danupon Nantajit [et al.] // J Cancer Res Clin Oncol – 2013. – Vol. 5. – P. 1-9. 39
40. The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis / G. Cazzanelli [et al.] // Cells. – 2018. – Vol. 7, № 2. – P. 1-14. 40
41. Thymidylate synthase gene polymorphism determines response and toxicity of 5-FUchemotherapy / ST Pullarkat [et al.] // The Pharmacogenomics Journal. – 2001. – Vol. 1. – P. 65-70.8
42. Von Hippel Lindau disease with colon adenocarcinoma, renal cell carcinoma and adrenal pheochromocytoma / L. Zinnamosca [et al.] // Intern Med. – 2013. – Vol. 52. – P. 1599-1603.38
